Skip Navigation

Briefings in Bioinformatics 2002 3(2):134-145; doi:10.1093/bib/3.2.134
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pedro, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pedro, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© Henry Stewart Publications

Emerging bioinformatics for the metabolome

Mendes Pedro
Computational biochemist who leads a research group on biochemical networks modelling in the Virginia Bioinformatics Institute. He wrote the simulation software Gepasi while at the University of Wales Aberystwyth. Current research is shared between biochemical simulation and metabolomics data management and analysis.


Pedro Mendes, Virginia Bioinformatics Institute, Virginia Polytechnic Institute State University (0477), 1880 Pratt Drive, Blacksburg, VA 24061, USA Fax: +1 540 231 2606 E-mail: mendes{at}vt.edu

Metabolic profiling applied to functional genomics (metabolomics) is in an early stage of development. Here, the technologies used for metabolite profiling are briefly covered, illustrated by a few pioneering studies. Issues related to bioinformatics, namely data analysis, visualisation and archival, are the main focus of this review. Arguably there is already a need for databases containing metabolite profiles specific for a single organism, and a generic repository containing all metabolite profiling results, regardless of species. Data analyses and visualisations that combine the biological context with chemistry details are suggested as being the most promising.

Keywords: metabolome, metabolite profiling, multivariate statistics, biochemical databases


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
R. Goodacre
Metabolomics of a Superorganism
J. Nutr., January 1, 2007; 137(1): 259S - 266S.
[Abstract] [Full Text] [PDF]

Home page
 Brief BioinformHome page
V. Shulaev
Metabolomics technology and bioinformatics
Brief Bioinform, June 1, 2006; 7(2): 128 - 139.
[Abstract] [Full Text] [PDF]

Home page
 Brief BioinformHome page
A. L. Castle, O. Fiehn, R. Kaddurah-Daouk, and J. C. Lindon
Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results
Brief Bioinform, June 1, 2006; 7(2): 159 - 165.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
D. M. Mutch, W. Wahli, and G. Williamson
Nutrigenomics and nutrigenetics: the emerging faces of nutrition
FASEB J, October 1, 2005; 19(12): 1602 - 1616.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
R. Goodacre
Making sense of the metabolome using evolutionary computation: seeing the wood with the trees
J. Exp. Bot., January 1, 2005; 56(410): 245 - 254.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. A. Milner
Molecular Targets for Bioactive Food Components
J. Nutr., September 1, 2004; 134(9): 2492S - 2498S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Y. Noguchi, R. Sakai, and T. Kimura
Metabolomics and its Potential for Assessment of Adequacy and Safety of Amino Acid Intake
J. Nutr., June 1, 2003; 133(6): 2097S - 2100.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.