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Briefings in Bioinformatics 2002 3(2):195-199; doi:10.1093/bib/3.2.195
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© Henry Stewart Publications

Software review

Computer programs for eukaryotic gene prediction

Vladimir Makarov
Staff scientist at the bioinformatics company BionomiX. Prior to that Dr Makarov developed bioinformatics knowledge management systems and algorithms at Paracel, a business of Celera Genomics, and at Ceres, Inc, as well as conducted research in structural and computational biology at the University of Houston and Baylor College of Medicine.


Vladimir A Makarov, Bionomix, Inc, 1055 E. Colorado Boulevard, Suite 550, Pasadena, CA 91106, USA Tel: +1 626 817 2244 Fax: +1 626 817 2201 E-mail: vladimir_makarov{at}hotmail.com

Seven popular programs for gene prediction in eukaryotic organisms are described and evaluated on the basis of availability for in-house and on-line use and prediction accuracy. This report outlines generally applicable approaches to computational gene prediction and known limitations in this field.

Keywords: gene structure, prediction, coding regions, gene finding, computational biology


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