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Briefings in Bioinformatics 2005 6(2):146-162; doi:10.1093/bib/6.2.146
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© Henry Stewart Publications

RNAi as a bioinformatics consumer

Ravi Sachidanandam
Works in Cold Spring Harbor Laboratory and is a physicist who is currently interested incomputational biology. He is working on several computational aspects in RNAi and its application as a tool for biological research. He is also working on various aspects of splicing, as well as modelling and simulating systems involved in apoptosis, splicing, RNAi and live-cell imaging.


Ravi Sachidanandam 1 Bungtown Road, Cold Spring Harbor Laboratory, NY 11724, USA Tel: +1 516 367 8864 Fax: +1 516 367 8389 E-mail: sachidan{at}cshl.org

RNAi has shown great potential for use as a tool for biological discovery, analysis and therapeutics. The involvement of the RNAi pathway in post-transcription silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics throws up several bioinformatics challenges. This paper delineates several areas of research and reviews work that has already been done, the tools that are available and the challenges that lie ahead.

Keywords: RNAi, miRNA, PTGS, TGS, gene silencing, chromatin


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