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Briefings in Bioinformatics 2005 6(2):163-177; doi:10.1093/bib/6.2.163
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© Henry Stewart Publications

Mathematical models of cell cycle regulation

Hendrik Fuß
PhD student of the Bioinformatics Research Group at the University of Ulster. His research project focuses on the analysis and modelling of protein kinase and phosphatase systems involved in the cell cycle

Werner Dubitzky
Chair in Bioinformatics and is Head of the Bioinformatics Research Group at the University of Ulster. His research interests include bioinformatics, systems biology, data and text mining, artificial intelligence and grid technology

C. Stephen Downes
Director of the Centre for Molecular Biosciences at the University of Ulster, and is Head of the Cancer and Ageing Research Group. His research interests include cell cycle checkpoint controls.

Mary Jo Kurth
Research Associate in the Cancer and Ageing Research Group at the University of Ulster. Her research interests include cell cycle checkpoint control, proteomics and systems biology


Hendrik Fuß, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, UK Tel.: +44 (0) 28 7032 3536 E-mail: fuss-h{at}ulster.ac.uk

The cell division cycle is a fundamental process of cell biology and a detailed understanding of its function, regulation and other underlying mechanisms is critical to many applications in biotechnology and medicine. Since a comprehensive analysis of the molecular mechanisms involved is too complex to be performed intuitively, mathematical and computational modelling techniques are essential. This paper is a review and analysis of recent approaches attempting to model cell cycle regulation by means of protein—protein interaction networks.

Keywords: cell cycle, computer simulation, systems biology, protein—protein interaction, regulatory networks


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