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Briefings in Bioinformatics 2005 6(2):189-193; doi:10.1093/bib/6.2.189
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© Henry Stewart Publications

Tutorial section

VEGA, the genome browser with a difference

Dr Jane Loveland
HAVANA Group, Wellcome Trust Sanger Institute Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK Tel: +44 (0) 1223 495389 Fax: +44 (0) 1223 494919 E-mail: jel{at}sanger.ac.uk

ABSTRACT

The Vertebrate Genome Annotation (Vega) database is a community resource for browsing manual annotation from a variety of vertebrate genomes of finished sequence (http://vega.sanger.ac.uk). Vega is different from other genome browsers as it has a standardised classification of genes which encompasses pseudogenes and non-coding transcripts. The data is manually curated, which is more accurate at identifying splice variants, pseudogenes poly(A) features, non-coding and complex gene structures and arrangements than current automated methods. The database also contains annotation from regions, not just whole genomes, and displays multiple species annotation (human, mouse, dog and zebrafish) for comparative analysis. Vega encourages community feedback that results in annotation updates and manual annotation of finished vertebrate sequence.

Keywords: vertebrate, annotation, database, manual, curation


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