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Briefings in Bioinformatics Advance Access originally published online on February 3, 2006
Briefings in Bioinformatics 2006 7(1):48-54; doi:10.1093/bib/bbk004
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© The Author 2006. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Studying statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the eukaryotic genomes

Irina Abnizova and Walter R. Gilks

Corresponding author. Irina Abnizova, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK. Tel: 01 223330385; Fax: 01 223 330388.irina.abnizova{at}mrc-bsu.cam.ac.uk

There are no well-known properties in regulatory DNA analogous to those in coding sequences; their spatial location is not regular, the consensus regulatory elements are often degenerate and there are no understandable rules governing their evolution. This makes it difficult to recognize regulatory regions within genome. We review developments in the statistical characterization of regulatory regions and methods of their recognition in eukaryotic genomes.

Keywords: regulatory regions, statistical methods, transcription factor binding sites


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