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Briefings in Bioinformatics Advance Access originally published online on October 31, 2006
Briefings in Bioinformatics 2007 8(2):96-108; doi:10.1093/bib/bbl038
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© The Author 2006. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Methods and protocols for prediction of immunogenic epitopes

Joo Chuan Tong, Tin Wee Tan and Shoba Ranganathan

Corresponding author. Shoba Ranganathan, Department of Chemistry and Biomolecular Sciences & Biotechnology Research Institute, Macquarie University, NSW 2109, Australia. Tel: + 61-2-9850-6262; Fax: + 61-2-9850-8313; E-mail: shoba.ranganathan{at}mq.edu.au

T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.

Keywords: MHC, antigens/peptides/epitopes, prediction

Submitted: June 2, 2006. Received (in revised form): September 14, 2006.


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