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Briefings in Bioinformatics Advance Access originally published online on January 17, 2008
Briefings in Bioinformatics 2008 9(3):189-197; doi:10.1093/bib/bbn001
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© The Author 2008. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Gene-set approach for expression pattern analysis

Dougu Nam and Seon-Young Kim

Corresponding author. Seon-Young Kim, Functional Genomics Research Center, KRIBB, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Korea. Tel: 82-42-879-8116; Fax: 82-42-879-8110; E-mail: kimsy{at}kribb.re.kr

Recently developed gene set analysis methods evaluate differential expression patterns of gene groups instead of those of individual genes. This approach especially targets gene groups whose constituents show subtle but coordinated expression changes, which might not be detected by the usual individual gene analysis. The approach has been quite successful in deriving new information from expression data, and a number of methods and tools have been developed intensively in recent years. We review those methods and currently available tools, classify them according to the statistical methods employed, and discuss their pros and cons. We also discuss several interesting extensions to the methods.

Keywords: gene set analysis, DNA microarray, differential expression of genes

Submitted: November 7, 2007. Received (in revised form): December 28, 2007.


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