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Briefings in Bioinformatics Advance Access published online on July 11, 2007
Briefings in Bioinformatics, doi:10.1093/bib/bbm028
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© The Author 2007. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Dynamical roles of biological regulatory circuits1

Denis Thieffry

Corresponding author. Denis Thieffry, INSERM ERM 206 - TAGC & Université de la Méditerranée, Campus Scientifique de Luminy, case 928, 13288 Marseille, Cedex 09 France. E-mail: thieffry{at}tagc.univ-mrs.fr

Regulatory circuits are found at the basis of all non-trivial dynamical properties of biological networks. More specifically, positive circuits are involved in the generation of multiple differentiated states, whereas negative circuits can generate cyclic or homeostatic behaviours. These notions are briefly reviewed, from initial biological formulations to mathematical formalisations, further encompassing their application to the design of synthetic regulatory systems. Finally, current challenges for the analysis of increasingly complex regulatory networks are indicated, as well as prospects for our understanding of development and evolution.

Keywords: Regulatory circuits, multistability, homeostasis, oscillations, synthetic biology, systems biology, dynamics

1This article is dedicated to René Thomas, for his inspiring pioneering contributions to Systems Biology

Submitted: March 31, 2007. Received (in revised form): June 4, 2007.


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