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Briefings in Bioinformatics Advance Access originally published online on February 3, 2006
Briefings in Bioinformatics 2006 7(1):116-120; doi:10.1093/bib/bbk009
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© Oxford University Press, 2006, All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Abstracts

The first 150 words of the full text of this article appear below.

Briefings in Bioinformatics aims to provide working biologists with an awareness and understanding of the computational approaches available for research and discovery. The Abstracts section of the journal consists of summaries of bioinformatics manuscripts published in the previous quarter. Inclusion of an article in this section indicates that the editors consider it to be among the most interesting and/or useful contributions to the field for the quarter covered. The contents of these reports are briefly distilled for the readers with an emphasis placed on their biological context and potential utility. Publications from the fourth quarter of 2005 (October–December) are reviewed here.

Alignments anchored on genomic landmarks can aid in the identification of regulatory elements
Kannan Tharakaraman, Leonardo Mariño-Ramírez, Sergey Sheetlin, David Landsman and John L. Spouge Bioinformatics (2005) Vol. 21, Suppl. 1, pp. i440–i448
One of the most important challenges facing bioinformatics is the characterization of regulatory sequences that control the timing and pattern of gene expression. Gene expression is controlled, to large extent, by the interaction of trans-regulatory proteins with their cis-regulatory DNA binding sites. Cis-regulatory sites tend to . . . [Full Text of this Article]

A genome-wide survey of structural variation between human and chimpanzee
Tera L. Newman, Eray Tuzun, V. Anne Morrison, Karen E. Hayden, Mario Ventura, Sean D. McGrath, Mariano Rocchi and Evan E. Eichler Genome Research (2005) Vol. 15, no. 10, pp. 1344–1356
Metabolic functions of duplicate genes in Saccharomyces cerevisiae
Lars Kuepfer, Uwe Sauer and Lars M. Blank Genome Research (2005) Vol. 15, no. 10, pp. 1421–1430
Ascertainment bias in studies of human genome-wide polymorphism
Andrew G. Clark, Melissa J. Hubisz, Carlos D. Bustamante, Scott H. Williamson, and Rasmus Nielsen Genome Research (2005) Vol. 15, no. 11, pp. 1496–1502
Natural selection on protein-coding genes in the human genome
Carlos D. Bustamante, Adi Fledel-Alon, Scott Williamson, Rasmus Nielsen, Melissa Todd Hubisz, Stephen Glanowski, David M. Tanenbaum, Thomas J. White, John J. Sninsky, Ryan D. Hernandez, Daniel Civello, Mark D. Adams, Michele Cargill and Andrew G. Clark Nature (2005) Vol. 437, no. 7062, pp. 1153–1157
Adaptive evolution of non-coding DNA in Drosophila
Peter Andolfatto Nature (2005) Vol. 437, no. 7062, pp.1149–1152
Two rounds of whole genome duplication in the ancestral vertebrate
Paramvir Dehal and Jeffrey L. Boore PLoS Biology (2005) Vol. 3, no. 10, p. e314
The design of transcription-factor binding sites is affected by combinatorial regulation
Yonatan Bilu and Naama Barkai Genome Biology (2005), Vol. 6, no. 12, p. R103
I. King Jordan

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