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Briefings in Bioinformatics Advance Access originally published online on March 31, 2007
Briefings in Bioinformatics 2007 8(5):378-379; doi:10.1093/bib/bbm010
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© The Author 2007. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Book reviews

Normal Mode Analysis Theoretical and Applications to Biological and Chemical Systems.

Normal Mode Analysis Theoretical and Applications to Biological and Chemical Systems.
Qiang Cui and Ivet Bahar
Chapman and Hall/CRC (Mathematical and Computational Biology Series).

The first 10% of the full text of this article appears below.

The realization that many of the important biochemical phenomena occur in the micro- to millisecond timescale has resulted in the need for computational methods that would extend beyond the nanosecond regime that is currently accessible with explicit-solvent molecular dynamics simulations. The normal mode analysis method, initially developed in solid-phase physics, met that need by enabling the exploration of large scale collective motions that occur in systems ranging from small proteins and nucleic acids to the bacterial ribosome. This method requires the derivation of eigenvectors and eigenvalues through the diagonalization of the Hessian matrix, which is composed of mass-weighed second derivatives of the potential energy function. The . . . [Full Text of this Article]

Samy Meroueh

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