Skip Navigation


Briefings in Bioinformatics Advance Access originally published online on February 3, 2006
Briefings in Bioinformatics 2006 7(1):55-69; doi:10.1093/bib/bbk005
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
7/1/55    most recent
bbk005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Florea, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Florea, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Bioinformatics of alternative splicing and its regulation

Liliana Florea

Liliana D. Florea, Department of Computer Science, George Washington Univeristy, Academic Center-Rm 714, Washington DC 20052. Tel: (202) 994-1057; Fax (202) 994-4875; florea{at}gwu.edu

The sequencing of the human genome and ensuing wave of data generation have brought new light upon the extent and importance of alternative splicing as an RNA regulatory mechanism. Alternative splicing could potentially explain the complexity of protein repertoire during evolution, and defects in the splicing mechanism are responsible for diseases as complex as cancer. Among the challenges that rise in light of these discoveries are cataloguing splice variation in the human and other eukaryotic genomes, and identifying and characterizing the splicing regulatory elements that control their expression. Bioinformatics efforts tackling these two questions are just at the beginning. This article is a survey of these methods.

Keywords: alternative splicing, gene indices, genome-based clustering, splice graph, splicing enhancers, splicing silencers


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
M. L. Tress, J.-J. Wesselink, A. Frankish, G. Lopez, N. Goldman, A. Loytynoja, T. Massingham, F. Pardi, S. Whelan, J. Harrow, et al.
Determination and validation of principal gene products
Bioinformatics, January 1, 2008; 24(1): 11 - 17.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
G. G. Leparc and R. D. Mitra
A sensitive procedure to detect alternatively spliced mRNA in pooled-tissue samples
Nucleic Acids Res., December 18, 2007; 35(21): e146 - e146.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. Foissac and M. Sammeth
ASTALAVISTA: dynamic and flexible analysis of alternative splicing events in custom gene datasets
Nucleic Acids Res., July 13, 2007; 35(suppl_2): W297 - W299.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.