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Briefings in Bioinformatics Advance Access originally published online on May 13, 2008
Briefings in Bioinformatics 2008 9(4):333-343; doi:10.1093/bib/bbn024
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© The Author 2008. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Bioinformatics, multiscale modeling and the IUPS Physiome Project

Peter J. Hunter, Edmund J. Crampin and Poul M. F. Nielsen

Corresponding author. Peter J. Hunter, Auckland Bioengineering Institute, The University of Auckland, 70 Symonds St, Auckland, New Zealand. Tel: +649-373-7599 x88395; Fax: +649-367-7157; E-mail: p.hunter{at}auckland.ac.nz

Multiscale modeling is required for linking physiological processes operating at the organ and tissue levels to signal transduction networks and other subcellular processes. Several XML markup languages, including CellML, have been developed to encode models and to facilitate the building of model repositories and general purpose software tools. Progress in this area is described and illustrated with reference to the heart Physiome Project which aims to understand cardiac arrhythmias in terms of structure-function relations from proteins up to cells, tissues and organs.

Keywords: multiscale modeling, Physiome Project, markup languages, CellML, FieldML

Submitted: March 4, 2008. Received (in revised form): April 8, 2008.


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