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Briefings in Bioinformatics Advance Access originally published online on December 10, 2008
Briefings in Bioinformatics 2008 9(6):518-531; doi:10.1093/bib/bbn038
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© The Author 2008. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Briefings in Bioinformatics issue: Special Issue:Database Integration in Life Sciences [View the issue table of contents]

Building a knowledge base for systems pathology

Holger Michael, Jennifer Hogan, Alexander Kel, Olga Kel-Margoulis, Frank Schacherer, Nico Voss and Edgar Wingender

Corresponding author. Edgar Wingender, Department of Bioinformatics, Goldschmidtstr. 1, D-37077 Göttingen, Germany. Tel: +49 (0)551 39 14912; Fax: +49 (0)551 39 14914; E-mail: e.wingender{at}med.uni-goettingen.de

Translating the exponentially growing amount of omics data into knowledge usable for a personalized medicine approach poses a formidable challenge. In this article—taking diabetes as a use case—we present strategies for developing data repositories into computer-accessible knowledge sources that can be used for a systemic view on the molecular causes of diseases, thus laying the foundation for systems pathology.

Keywords: databases, content integration, systems pathology, personalized medicine

Submitted: June 3, 2008. Received (in revised form): August 14, 2008.


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