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Briefings in Bioinformatics Advance Access published online on September 2, 2006
Briefings in Bioinformatics, doi:10.1093/bib/bbl030
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© The Author 2006. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org
Received April 20, 2006
Accepted July 20, 2006

Original Papers

HCOP: a searchable database of human orthology predictions

Tina A. Eyre, Mathew W. Wright, Michael J. Lush, and Elspeth A. Bruford *

* To whom correspondence should be addressed.
Elspeth A. Bruford, E-mail: nome{at}galton.ucl.ac.uk


  Abstract

The HUGO Gene Nomenclature Committee (HGNC) Comparison of Orthology Predictions (HCOP) search tool combines the human, mouse, rat and chicken orthology assertions made by PhIGs, HomoloGene, Ensembl, Inparanoid, Mouse Genome Informatics (MGI) and HGNC, enabling users to identify predicted ortholog pairs for a specified gene or genes. The HCOP resource provides a useful method to integrate, compare and access a variety of disparate sources of human orthology data.

The HCOP search tool, data and documentation are available at http://www.gene.ucl.ac.uk/hcop.

Keywords: orthology; nomenclature; database; comparative; genes.

Tina A. Eyre obtained her PhD in bioinformatics with Janet Thornton at UCL in 2005, before working as a bioinformatician for the HUGO Gene Nomenclature Committee for 18 months. In May 2006 she moved to the Sanger Institute, where she currently works as a Senior Computer Biologist.

Mathew W. Wright received his PhD in Neuroscience from University College London; in 2000 he joined the HUGO Gene Nomenclature Committee (HGNC) and in 2004 was appointed as the HGNC's HUMOT (Human and Mouse Orthologous Annotation) editor.

Michael J. Lush received his PhD at Leicester University entitled ‘Molecular cloning of Neuropathy Target Esterase’. Subsequently taking a position cloning T-cell antigens and autoantigens in psoriasis (Leicester University). In 2000, he joined the HUGO Gene Nomenclature Committee providing vital Bioinformatics support.

Elspeth A. Bruford received her PhD mapping retinal diseases at the MRC Human Genetics Unit, Edinburgh. After working in publishing, she moved to University College London in 1998 to join the HUGO Gene Nomenclature Committee, of which she is now the Project Co-ordinator.


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