Skip Navigation



Briefings in Bioinformatics Advance Access published online on September 26, 2006
Briefings in Bioinformatics, doi:10.1093/bib/bbl032
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
8/2/78    most recent
bbl032v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Fariselli, P.
Right arrow Articles by Casadio, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fariselli, P.
Right arrow Articles by Casadio, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 8, 2006
Accepted August 9, 2006

Original papers

The WWWH of remote homolog detection: The state of the art

Piero Fariselli *, Ivan Rossi, Emidio Capriotti, and Rita Casadio

* To whom correspondence should be addressed.
Piero Fariselli, E-mail: piero{at}biocomp.unibo.it


  Abstract

The detection of remote homolog pairs of proteins using computational methods is a pivotal problem in structural bioinformatics, aiming to compute protein folds on the basis of information in the database of known structures. In the last 25 years, several methods have been developed to tackle this problem, based on different approaches including sequence-sequence alignments and/or structure comparison. In this article, we will briefly discuss When, Why, Where and How (WWWH) to perform remote homology search, reviewing some of the most widely adopted computational approaches. The specific aim is highlighting the basic criteria implemented by different research groups and commenting on the status of the art as well as on still-open questions.

Keywords: remote homolog detection; protein structure prediction; sequence alignment; threading; fold recognition.

Piero Fariselli has a PhD in Biophysics and is currently a permanent researcher at the University of Bologna. His main research interests concern structural bioinformatics and machine learning.

Ivan Rossi is the President of BioDec, a Bioinformatic software house, and Adjunct Professor of Computational Biology at the University of Bologna. He has a PhD in Computational Chemistry.

Emidio Capriotti is a Postdoctoral Fellow at the Biocomputing Group. His research concerns different aspects of protein folding related to the prediction of 3D structure, folding kinetics and protein stability.

Rita Casadio is a full Professor of Biochemistry/Bioinformatics and Group Leader of the Biocomputing Group of the Bologna University. Her work is devoted to different problems of computational biology and bioinformatics, including protein structure prediction and sequence analysis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.