Skip Navigation



Briefings in Bioinformatics Advance Access published online on October 13, 2006
Briefings in Bioinformatics, doi:10.1093/bib/bbl036
This Article
Right arrow Full Text (Rapid PDF)
Right arrow Supplementary data
Right arrow All Versions of this Article:
7/4/318    most recent
bbl036v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ng, A.
Right arrow Articles by Zvelebil, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ng, A.
Right arrow Articles by Zvelebil, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 6, 2006
Accepted September 6, 2006

Original papers

Resources for integrative systems biology: from data through databases to networks and dynamic system models

Aylwin Ng, Borisas Bursteinas, Qiong Gao, Ewan Mollison, and Marketa Zvelebil *

* To whom correspondence should be addressed.
Marketa Zvelebil, E-mail: marketa{at}ludwig.ucl.ac.uk


  Abstract

In systems biology, biologically relevant quantitative modelling of physiological processes requires the integration of experimental data from diverse sources. Recent developments in high-throughput methodologies enable the analysis of the transcriptome, proteome, interactome, metabolome and phenome on a previously unprecedented scale, thus contributing to the deluge of experimental data held in numerous public databases. In this review, we describe some of the databases and simulation tools that are relevant to systems biology and discuss a number of key issues affecting data integration and the challenges these pose to systems-level research.

Keywords: bioinformatics; systems biology; database and knowledgebase; dynamic modelling; networks and modules; data integration.

Aylwin Ng is a postdoctoral research fellow at the Ludwig Institute. His background spans computational biology, immunology and virology. His research is in integrative systems biology and involves defining networks and functional modules in inflammatory processes.

Borisas Bursteinas is a postdoctoral research fellow at the Ludwig Institute. His background is in distributed data mining and software engineering. His current research is in computational systems biology.

Qiong Gao is a scientific officer at the Ludwig Institute. She has a dual background in chemistry and computer science. She is involved in the design and development of a variety of analytical tools and bioinformatics software.

Ewan Mollison has a background in Microbiology, Biotechnology and Bioinformatics. He is a scientific officer at the Ludwig Institute and is currently involved in data curation and integration.

Marketa Zvelebil is the group leader of Bioinformatics and Systems Biology at the Ludwig Institute. Her background is in structural bioinformatics. She is involved in bioinformatic analysis of proteomics and structural studies of PI-3 kinases and other drug-ligand interactions.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
E. A. Houseman, B. C. Christensen, M. R. Karagas, M. R. Wrensch, H. H. Nelson, J. L. Wiemels, S. Zheng, J. K. Wiencke, K. T. Kelsey, and C. J. Marsit
Copy number variation has little impact on bead-array-based measures of DNA methylation
Bioinformatics, August 15, 2009; 25(16): 1999 - 2005.
[Abstract] [Full Text] [PDF]

Home page
 J R Soc InterfaceHome page
L. Endler, N. Rodriguez, N. Juty, V. Chelliah, C. Laibe, C. Li, and N. Le Novere
Designing and encoding models for synthetic biology
J R Soc Interface, August 6, 2009; 6(Suppl_4): S405 - S417.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. D. Kearns and A. Hoffmann
Integrating Computational and Biochemical Studies to Explore Mechanisms in NF-{kappa}B Signaling
J. Biol. Chem., February 27, 2009; 284(9): 5439 - 5443.
[Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
C. Zhang, O. Crasta, S. Cammer, R. Will, R. Kenyon, D. Sullivan, Q. Yu, W. Sun, R. Jha, D. Liu, et al.
An emerging cyberinfrastructure for biodefense pathogen and pathogen host data
Nucleic Acids Res., January 11, 2008; 36(suppl_1): D884 - D891.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Lechat, L. Hummel, S. Rousseau, and I. Moszer
GenoList: an integrated environment for comparative analysis of microbial genomes
Nucleic Acids Res., January 11, 2008; 36(suppl_1): D469 - D474.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.