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Briefings in Bioinformatics Advance Access published online on August 9, 2007
Briefings in Bioinformatics, doi:10.1093/bib/bbm033
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© The Author 2007. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Modelling and simulation techniques for membrane biology

Kevin Burrage, John Hancock, André Leier and Dan V. Nicolau, Jr

Corresponding author. Kevin Burrage, The Advanced Computational Modelling Centre and the ARC Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia. Tel: +61-7-3365-3487; Fax: +61-7-3365 6136; E-mail: kb{at}maths.uq.edu.au

One of the most important aspects of Computational Cell Biology is the understanding of the complicated dynamical processes that take place on plasma membranes. These processes are often so complicated that purely temporal models cannot always adequately capture the dynamics. On the other hand, spatial models can have large computational overheads. In this article, we review some of these issues with respect to chemistry, membrane microdomains and anomalous diffusion and discuss how to select appropriate modelling and simulation paradigms based on some or all the following aspects: discrete, continuous, stochastic, delayed and complex spatial processes.

Keywords: spatial and stochastic modelling, bio-chemical kinetics, multi-scale simulation, systems biology

Submitted: March 31, 2007. Received (in revised form): June 18, 2007.


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