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Briefings in Bioinformatics Advance Access published online on April 24, 2008
Briefings in Bioinformatics, doi:10.1093/bib/bbn016
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© The Author 2008. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation

Edgar Wingender

Corresponding author. Edgar Wingender, Department of Bioinformatics, Medical School, University of Göttingen, Goldschmidtstr. 1, D-37077 Göttingen, Germany. E-mail: e.wingender{at}med.uni-goettingen.de

Since its beginning as a data collection more than 20 years ago, the TRANSFAC project underwent an evolution to become the basis for a complex platform for the description and analysis of gene regulatory events and networks. In the following, I describe what the original concepts were, what their present status is and how they may be expected to contribute to future system biology approaches.

Keywords: TRANSFAC database, transcription regulation, gene expression analysis, pathway analysis

Submitted: January 21, 2008. Received (in revised form): March 11, 2008.


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