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Briefings in Bioinformatics Advance Access published online on May 22, 2008
Briefings in Bioinformatics, doi:10.1093/bib/bbn025
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© The Author 2008. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Critical technologies for bioinformatics

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Scientific advances over the last 50 years have provided a basis for parallel revolutions in engineering and in biomedicine. Advances in automation and miniaturization have enabled the development of modern instrumentation that supports large-scale measurement of biological entities. The burgeoning fields of genomics and proteomics, as well as other ‘omics’, keep generating large amounts of molecular expression and interaction data. Advances in cytometry enable quantification of cellular states and related functional properties. The latest scanning and imaging technologies have made it possible to scan and make detailed measurements of whole organisms. Clinical data complement biological data, enabling detailed descriptions of various healthy and diseased states, progression and responses to therapies. The availability of data representing . . . [Full Text of this Article]

Vladimir Brusic1 and Shoba Ranganathan2
1Dana-Farber Cancer Institute, Boston, MA 02115, USA
2Macquarie University, Sydney, NSW 2109, Australia


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