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Briefings in Bioinformatics Advance Access published online on January 16, 2009
Briefings in Bioinformatics, doi:10.1093/bib/bbn057
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Published by Oxford University Press 2009.

Domain mobility in proteins: functional and evolutionary implications

Malay Kumar Basu, Eugenia Poliakov and Igor B. Rogozin

Corresponding author. Malay Kumar Basu, J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA. Tel: +1 301 795 7890; Fax: +1 301 795 7060; E-mail: malaykbasu{at}gmail.com

A substantial fraction of eukaryotic proteins contains multiple domains, some of which show a tendency to occur in diverse domain architectures and can be considered mobile (or ‘promiscuous’). These promiscuous domains are typically involved in protein–protein interactions and play crucial roles in interaction networks, particularly those contributing to signal transduction. They also play a major role in creating diversity of protein domain architecture in the proteome. It is now apparent that promiscuity is a volatile and relatively fast-changing feature in evolution, and that only a few domains retain their promiscuity status throughout evolution. Many such domains attained their promiscuity status independently in different lineages. Only recently, we have begun to understand the diversity of protein domain architectures and the role the promiscuous domains play in evolution of this diversity. However, many of the biological mechanisms of protein domain mobility remain shrouded in mystery. In this review, we discuss our present understanding of protein domain promiscuity, its evolution and its role in cellular function.

Keywords: mobile domain, promiscuous domain, domain network, domain architecture, domain evolution

Submitted: September 4, 2008. Received (in revised form): December 8, 2008.


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